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Abstract #1108

Effective oxygen diffusivity mapping with multiparametric quantitative BOLD and pCASL: Comparison between healthy young and elderly subjects

Jan Kufer1, Jens Goettler1,2,3, Samira Epp1, Mikkel Bo Hansen4, Claus Zimmer1, Kim Mouridsen4, Fahmeed Hyder2, Christine Preibisch1,5, and Stephan Kaczmarz1,2
1School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3School of Medicine, Department of Radiology, Technical University of Munich, Munich, Germany, 4Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, 5School of Medicine, Clinic of Neurology, Technical University of Munich, Munich, Germany

The effective oxygen diffusivity (EOD) of the capillary bed has gained increasing interest as a promising biomarker providing additional information on microvascular integrity. To overcome limitations in the applicability of existing and relatively complex EOD mapping techniques, we proposed a novel more easily applicable MR-based approach. We measured EOD in 16 young and 30 elderly healthy subjects. Our measurements of EOD by MRI in young subjects yielded comparably good results in comparison with PET-data as a reference. Furthermore, we found EOD reductions in elderly healthy subjects with concomitant capillary transit-time heterogeneity (CTH) increases, indicating disturbed capillary oxygen extraction ability.

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