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Abstract #1109

Voxel-wise CMRO2 mapping reveals focally-reduced task-related oxygen consumption in multiple sclerosis

Eleonora Patitucci1, Rachael C Stickland 2, Hannah L Chandler1, Michael Germuska1, Catherine Foster1, Sharmila Khot1, Neeraj Saxena1, Valentina Tomassini1,3, and Richard G Wise1,3
1CUBRIC - Cardiff University Brain Research Imaging Centre -Psychology, Cardiff University, Cardiff, United Kingdom, 2Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3Institute for Advanced Biomedical Technologies (ITAB), Department of Neurosciences, Imaging and Clinical Sciences, University of Chieti-Pescara “G. d’Annunzio”, Chieti, Italy

Calibrated fMRI can map the rate of cerebral oxygen consumption of the human brain, offering an important indicator of energy dysfunction in neurodegenerative and neuroinflammatory diseases. Previous studies investigated oxygen metabolism at rest or in response to tasks within BOLD signal defined region of interests (ROIs). Here, we investigate on a voxel-by-voxel basis the oxygen metabolic activity in patients with multiple sclerosis during the execution of a task. We show the feasibility of mapping task-induced CMRO2 changes, demonstrating reduced oxygen consumption in the basal ganglia in MS patients that was not otherwise evident from BOLD or CBF signals.

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