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Abstract #1110

Venular Cerebral Blood Volume (vCBV) Mapping Using Fourier-Transform Based Velocity-Selective Pulse Trains

Wenbo Li1,2, Peter van Zijl1,2, and Qin Qin1,2
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

A new method is proposed to quantify the venular cerebral blood volume (vCBV) by using Fourier-transform based velocity-selective inversion (FT-VSI) to null the arterial blood signal while using Fourier-transform based velocity-selective saturation (FT-VSS) to suppress the tissue signal. Compared to previous schemes, the proposed method potentially has higher SNR and is more robust to tissue signal fluctuations attributed to system instabilities and physiological motion. The contamination of cerebrospinal fluid (CSF) signal is also corrected for by taking an extra image at a second echo with long TE. Using this method, vCBV of five volunteers were measured at 3T.

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