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Abstract #1113

Comparison of calibrated fMRI with calibration factor M determined by hypercapnia vs. gas-free R2'

Stephan Kaczmarz1,2, Jan Kufer1, Lena Schmitzer1, Jens Göttler1,2,3, Mario Eduardo Archila Melendez1, Andreas Hock4, Christian Sorg1, Claus Zimmer1, Fahmeed Hyder2, and Christine Preibisch1,5
1School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3School of Medicine, Department of Radiology, Technical University of Munich, Munich, Germany, 4Philips Healthcare, Hamburg, Germany, 5School of Medicine, Clinic of Neurology, Technical University of Munich, Munich, Germany

Calibrated-fMRI is highly promising to quantify human brain function via mapping changes of cerebral metabolic rate of oxygen. While the R2’-based approach is easily applicable, systematic differences to the well-established hypercapnia-calibration have been reported. We present data from an ongoing study in seven healthy young subjects correlating calibration factors M from R2' vs. hypercapnia. We hypothesized better correlation after methodological improvements in R2'-mapping and pseudo-continuous arterial spin labeling (pCASL). Our results confirmed this hypothesis, with good correlations between both fMRI-calibrations. However, we found potentially confounding hypercapnia effects on pCASL. Thus, our results suggest benefits of gas-free R2’-calibration for future applications.

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