The Thigh Cuff Challenge (TCC) technique is a promising method for assessing dynamic cerebral autoregulation with fMRI. A TCC fMRI experiment was performed in order to better understand the BOLD fMRI signal changes associated with autoregulation. We demonstrate that TCC event-locked cortical fMRI signal changes are widespread across cortical grey matter, with varying response shape both within and between subjects. The TCC BOLD response is on average ~0.3%, which we estimate on a voxel-wise basis using a novel informed basis set, which provides a proof-of-concept demonstrating the potential of TCC and fMRI to probe cerebrovascular function.
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