Abstract #1115

Effect of inhibitory neural activities to BOLD fMRI

Hyun Seok Moon^1,2, Haiyan Jiang¹, Won Beom Jung^1,2, JungMi Lee¹, Gunsoo Kim¹, and Seong-Gi Kim^1,2

¹Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, ²Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

BOLD fMRI combined with optogenetics allows for brain-wide neural network studies. Most studies have focused on activity of excitatory neurons, which is presumably to contribute BOLD fMRI dominantly. However, fMRI response evoked by inhibitory neural activities is unknown. Here, we investigated 15.2T BOLD response of optogenetically stimulated GABAergic neural activation, and verified the results with electrophysiology.

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