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Abstract #1130

Magnetic Resonance Fingerprinting with Quadratic RF Phase for Continuous Temperature Monitoring in Aqueous Tissues

Rasim Boyacioglu1, Megan Poorman2,3, Kathryn Keenan2, and Mark Griswold1
1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Physical Measurement Laboratory, National Institute of Standards and Technology, Boulder, CO, United States, 3Department of Physics, University of Colorado Boulder, Boulder, CO, United States

Conventional temperature monitoring is based on measurement of off-resonance via gradient-echo phase scans for non-adipose tissue. MRF with quadratic RF phase (MRFqRF) simultaneously quantifies off-resonance, T1, T2, and T2*. For a proof of principle thermometry experiment with MRFqRF, an ex-vivo aqueous sample was heated with laser ablation, temperature was tracked, and multiple continuous MRFqRF scans were obtained with different temporal resolutions. Scanner frequency drifts were removed automatically with Independent Component Analysis. Residual changes in off-resonance predict the temperature change. However, MRFqRF temporal resolution (~10s) needs to be increased further for clinical relevance.

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