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Abstract #1129

Temperature Triggered Release of a Protein from Thermoresponsive Nanogels Using Thermal Magnetic Resonance

Yiyi Ji1, Lukas Winter2, Lucila Navarro3,4, Min-Chi Ku1, João Periquito1, Michal Pham1, Werner Hoffmann2, Loryn E. Theune3, Marcelo Calderón3,5,6, and Thoralf Niendorf1,7
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, 2Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, 3Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany, 4Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral (UNL) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina, 5POLYMAT and Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain, 6IKERBASQUE, Basque Foundation for Science, Bilbao, Spain, 7Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany

Thermal Magnetic Resonance (ThermalMR) adds a thermal dimension to an MR device by exploiting the constructive interference of radiofrequency (RF) waves for temperature intervention. Here, the capacity of ThermalMR is demonstrated in a model system involving the release of a protein from thermoresponsive nanogels. Upon RF heating the nanogels (T=43°C), 29.3% of the protein were released after 6h which is in accordance with the release profile obtained for the reference data derived from a water bath setup. ThermalMR provides an ideal testbed for the study of temperature induced release of drugs, MR probes and other agents from thermoresponsive carriers.

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