Abstract #1129

Temperature Triggered Release of a Protein from Thermoresponsive Nanogels Using Thermal Magnetic Resonance

Yiyi Ji¹, Lukas Winter², Lucila Navarro^3,4, Min-Chi Ku¹, João Periquito¹, Michal Pham¹, Werner Hoffmann², Loryn E. Theune³, Marcelo Calderón^3,5,6, and Thoralf Niendorf^1,7

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, ²Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany, ³Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany, ⁴Instituto de Desarrollo Tecnológico para la Industria Química (INTEC), Universidad Nacional del Litoral (UNL) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina, ⁵POLYMAT and Applied Chemistry Department, Faculty of Chemistry, University of the Basque Country UPV/EHU, Donostia-San Sebastián, Spain, ⁶IKERBASQUE, Basque Foundation for Science, Bilbao, Spain, ⁷Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, Germany

Thermal Magnetic Resonance (ThermalMR) adds a thermal dimension to an MR device by exploiting the constructive interference of radiofrequency (RF) waves for temperature intervention. Here, the capacity of ThermalMR is demonstrated in a model system involving the release of a protein from thermoresponsive nanogels. Upon RF heating the nanogels (T=43°C), 29.3% of the protein were released after 6h which is in accordance with the release profile obtained for the reference data derived from a water bath setup. ThermalMR provides an ideal testbed for the study of temperature induced release of drugs, MR probes and other agents from thermoresponsive carriers.

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