For patients suspected to have spinal metastasis, a confirmed pathological diagnosis is needed to proceed with appropriate treatment. This study applied quantitative radiomics to differentiate 5 groups of patients with metastatic cancers in the spine, including 28 lung, 11 breast, 7 kidney, 11 prostate and 18 thyroid. The analysis was done on post-contrast images. A total of 107 features, including 32 first order and 75 texture, were extracted for each case by using PyRadiomics. The group differentiation was done by using multi-class support vector machine (SVM). The overall accuracy was 80%, with the highest accuracy of 27/28=96% for lung mets.