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Abstract #1151

Imaging of Bone-Synovium Interactions Using Dynamic Contrast Enhanced MRI and 18F-Sodium Fluoride PET

James MacKay1,2, Lauren Watkins3, Garry Gold3, and Feliks Kogan4
1Radiology, University of East Anglia, Norwich, United Kingdom, 2Radiology, University of Cambridge, Cambridge, United Kingdom, 3Radiology, Stanford University, Stanford, CA, United States, 4Stanford University, Stanford, CA, United States

Synovial inflammation is hypothesised to play a role in the development and progression of osteophytes in osteoarthritis (OA).

Here we use hybrid 3T PET-MRI to perform simultaneous bilateral knee MR imaging of 11 participants (22 knees) with knee OA. We use 18F-NaF PET to quantify osteophyte metabolic activity and dynamic contrast enhanced MR imaging to quantify synovitis.

We demonstrate that synovitis adjacent to osteophytes is more intense (as quantified by the DCE parameter Ktrans) than the whole-joint average, and that there is a significant association between increased osteophyte metabolic activity (as quantified by PET SUVmax) and intensity of adjacent synovitis.

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