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Abstract #1161

A new Trabecular BV/TV Estimation Method using Single-Sided NMR Devices through the Separation between Intra- and Inter-trabecular 1H Signals

Marco Barbieri1, Paola Fantazzini1, Anna Festa2, Fabio Baruffaldi2, Claudia Testa1, and Leonardo Brizi1
1Physics and Astronomy, University of Bologna, Bologna, Italy, 2IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

Methods to improve the early detection of diseases associated with an increased bone fragility are objects of investigation. Single-sided NMR is an appealing approach for medical applications. In this work we propose a new methodology to assess the bone volume fraction (BV/TV) of trabecular bone (TB), without the need of using a reference sample, exploiting the separation between intra- and inter-trabecular 1H signals from quasi-continuous T2 distributions. BV/TV of TB samples estimated using NMR were found in strong agreement with micro-CT estimations. This is promising for the application of single-sided NMR scanners to in-vivo assessing of bone micro-structure.

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