Abstract #1163

Quantitative 3D ultrashort echo time Cones magnetization transfer (3D UTE-Cones-MT) magnetic resonance imaging of knee cartilage degeneration

Yanping Xue^1,2, Yajun Ma¹, Zhao Wei¹, Francis Tang¹, Mei Wu¹, Saeed Jerban¹, Eric Y Chang^1,3, and Jiang Du¹

¹University of California, San Diego, San Diego, CA, United States, ²Radiology, Beijing Chao-Yang Hospital, Beijing, China, ³VA San Diego Healthcare System, San Diego, CA, United States

Quantitative MRI biomarkers, such as T2, T2*, and T1rho have been used to detect cartilage degeneration. However, these biomarkers are sensitive to the magic angle effect. Magnetization transfer (MT) modeling provides magic angle insensitive parameters such as macromolecular proton fraction (MMF). This study focuses on the clinical evaluation of cartilage degeneration using 3D ultrashort echo time cones MT (3D UTE-Cones-MT) modeling in osteoarthritis (OA) patients. Both MMF and MT ratio (MTR) show significant negative correlations with WORMS grading of knee cartilage. This study highlights the potential of 3D UTE-Cones-MT techniques for detection of early cartilage degeneration in OA.

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