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Abstract #1175

Towards minimal T1 and B1 contributions in cervical spinal cord inhomogeneous magnetization transfer imaging

Arash Forodighasemabadi1,2,3,4, Thomas Troalen5, Lucas Soustelle1,2, Guillaume Duhamel1,2, Olivier Girard1,2, and Virginie Callot1,2,4
1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France, 3Aix-Marseille Univ, IFSTTAR, LBA, Marseille, France, 4iLab-Spine International Research Laboratory, Marseille-Montréal, France, 5Siemens Healthcare SAS, Saint-Denis, France

Inhomogeneous Magnetization Transfer (ihMT) is a promising MRI technique, sensitive to myelinated tissue that can be used to study demyelinating pathologies such as MS. But the conventional MT and ihMT ratio metrics could be sensitive to T1 and B1 variations, especially in the context of spinal cord imaging. In order to minimize these effects, this study focuses on 3D ihMT-RAGE sequence with high FA reference acquisition and ihMTR inverse metric computation. The quantifications within GM and WM along the cervical spinal cord demonstrate that this technique is promising for investigating SC pathologies.

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