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Abstract #1176

Regional and longitudinal changes of multiple MRI parametersĀ correlate with behavioral impairment and recovery after spinal cord injury

Feng Wang1,2, Tung-Lin Wu1, Pai-Feng Yang1,2, Nellie E. Byun1, Li Min Chen1,2, and John C. Gore1,2,3
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Quantitative magnetization transfer (qMT) and diffusion tensor imaging (DTI) may detect and track compositional and structural changes in spinal cords before and after injury and during repair. This study aims to systematically evaluate the abilities of the qMT-derived pool size ratio (PSR) and DTI-derived diffusion parameters to assess injury-associated regional changes in spinal cords of monkeys, and to correlate them to specific sensorimotor behaviors. An overall goal is to evaluate the relationships between longitudinal changes in different regional MRI measures and sensorimotor behavioral impairment and recovery following spinal cord injury over a long period of time (months).

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