Abstract #1176

Regional and longitudinal changes of multiple MRI parameters correlate with behavioral impairment and recovery after spinal cord injury

Feng Wang^1,2, Tung-Lin Wu¹, Pai-Feng Yang^1,2, Nellie E. Byun¹, Li Min Chen^1,2, and John C. Gore^1,2,3

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Quantitative magnetization transfer (qMT) and diffusion tensor imaging (DTI) may detect and track compositional and structural changes in spinal cords before and after injury and during repair. This study aims to systematically evaluate the abilities of the qMT-derived pool size ratio (PSR) and DTI-derived diffusion parameters to assess injury-associated regional changes in spinal cords of monkeys, and to correlate them to specific sensorimotor behaviors. An overall goal is to evaluate the relationships between longitudinal changes in different regional MRI measures and sensorimotor behavioral impairment and recovery following spinal cord injury over a long period of time (months).

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