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Abstract #1181

Structural MRI investigation caudal to degenerative cervical myelopathy: a clinical MRI application

Kevin Vallotton1, Maryam Seif1, Markus Hupp1, Armin Curt1, and Patrick Freund1,2,3
1Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, Switzerland, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

Degenerative cervical myelopathy (DCM) is the most common form of non-traumatic spinal cord injury (SCI) and induces neurodegeneration in the cervical cord at and above the primary stenosis level. However, whether similar neurodegeneration occurs at the lumbar level remains unclear. We therefore applied high resolution T2*-weighted MRI in the lumbar cord in both DCM patients and healthy controls to investigate potential injury-induced structural changes. Significant atrophy was found in mild DCM patients and its magnitude was associated with sensory impairment.

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