Abstract #1182

Spinal cord and brain DTI alterations in cervical spondylotic myelopathy (CSM)

Rebecca Sara Samson¹, Jonathan Stutters¹, Muhammad Ali Akbar², Armin Curt³, Julien Cohen-Adad^4,5, Michael Fehlings^2,6, Patrick Freund^3,7,8, Blair Innerarity¹, Maryam Seif³, Carmen Tur¹, and Claudia A. M. Gandini Wheeler-Kingshott^1,9,10

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, University College London, London, United Kingdom, ²Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ³Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, ⁴NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ⁵Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, ⁶Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁷Department of Neurophysics, Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, ⁸Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁹Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ¹⁰Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

We explored diffusion tensor imaging (DTI) metrics along the corticospinal tract (CST) from the cervical cord to the motor cortex, measured using separate brain and cervical cord DTI protocols in healthy subjects and cervical spondylotic myelopathy (CSM) patients at two sites. Instead of looking at either brain or cord separately, here, we combine brain and cord measurements and examine how the CST is affected in CSM, in addition to exploring correlations with clinical measures. Statistically significant changes were observed between CSM and HC when comparing cord and brain CST data, demonstrating the sensitivity of CST metrics to cord pathology.

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