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Abstract #1182

Spinal cord and brain DTI alterations in cervical spondylotic myelopathy (CSM)

Rebecca Sara Samson1, Jonathan Stutters1, Muhammad Ali Akbar2, Armin Curt3, Julien Cohen-Adad4,5, Michael Fehlings2,6, Patrick Freund3,7,8, Blair Innerarity1, Maryam Seif3, Carmen Tur1, and Claudia A. M. Gandini Wheeler-Kingshott1,9,10
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, University College London, London, United Kingdom, 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada, 3Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 4NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 5Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, 6Krembil Research Institute, University Health Network, Toronto, ON, Canada, 7Department of Neurophysics, Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom, 8Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 9Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 10Brain MRI 3T Center, IRCCS Mondino Foundation, Pavia, Italy

We explored diffusion tensor imaging (DTI) metrics along the corticospinal tract (CST) from the cervical cord to the motor cortex, measured using separate brain and cervical cord DTI protocols in healthy subjects and cervical spondylotic myelopathy (CSM) patients at two sites. Instead of looking at either brain or cord separately, here, we combine brain and cord measurements and examine how the CST is affected in CSM, in addition to exploring correlations with clinical measures. Statistically significant changes were observed between CSM and HC when comparing cord and brain CST data, demonstrating the sensitivity of CST metrics to cord pathology.

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