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Abstract #1201

Estimating Blood Volume with Ferumoxytol at 0.55 T

Daniel A. Herzka1, Rajiv A. Ramasawmny1, Toby Rogers1, Kendall O'Brien1, Delaney McGuirt1, Adrienne Campbell-Washburn1, and Robert J. Lederman1
1National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States

Off-label use of ferumoxytol as an intravascular contrast agent for cardiovascular imaging is increasing. Measurements of circulating blood volume using dilution techniques has been previously demonstrated with ferumoxytol at 1.5 T. The relaxivity of ferumoxytol at low field (0.55 T) is increased, making it an attractive approach potentially requiring reduced dosages. Here we successfully demonstrate the feasibility of measurement of total circulating blood volume at lower field strength in swine.

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