Off-label use of ferumoxytol as an intravascular contrast agent for cardiovascular imaging is increasing. Measurements of circulating blood volume using dilution techniques has been previously demonstrated with ferumoxytol at 1.5 T. The relaxivity of ferumoxytol at low field (0.55 T) is increased, making it an attractive approach potentially requiring reduced dosages. Here we successfully demonstrate the feasibility of measurement of total circulating blood volume at lower field strength in swine.
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