Abstract #1202

Microstructural cardiac remodelling in aortic stenosis and its reversibility following valve replacement – a CMR diffusion tensor imaging study

Alexander Gotschy^1,2,3, Constantin von Deuster¹, Lucas Weber⁴, Mareike Gastl⁵, Martin O. Schmiady⁶, Robbert J. H. van Gorkum¹, Jochen von Spiczak^1,4, Robert Manka^2,4, Sebastian Kozerke¹, and Christian T. Stoeck¹

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, ³Great Ormond Street Hospital, London, United Kingdom, ⁴Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ⁵Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Duesseldorf, Duesseldorf, Germany, ⁶Department of Cardiac Surgery, University Hospital Zurich, Zurich, Switzerland

CMR diffusion tensor imaging (CMR DTI) allows for the assessment of cardiac microstructure in diseased hearts. We investigated changes of myocardial diffusion properties and myocyte orientation in patients with aortic stenosis (AS) before and after valve replacement (AVR) using DTI and T1-mapping. Mean diffusivity (MD), fractional anisotropy (FA), E2A sheet angle and the transmural helix angle (HA)-slope were altered in AS patients, while native T1 was not significantly different. After AVR, the HA-slope was the only parameter with reversible changes, whereas MD, FA and E2A remained abnormal. This study indicates that AS-induced alterations of myocardial microstructure partly persist following AVR.

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