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Abstract #1203

Cardiac Rhythm Impacts Left Atrial Hemodynamics Measured with 4D Flow and Real Time PC MRI in Controls and Patients with Atrial Fibrillation

Amanda L DiCarlo1, Hassan Haji-Valizadeh2, Suvai Gunasekaran1, Patrick McCarthy3, Rod Passman4, Philip Greenland4, Daniel C Lee1, Daniel Kim1, and Michael Markl1,5
1Radiology, Northwestern University, Chicago, IL, United States, 2Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States, 3Cardiac Surgery, Northwestern University, Chicago, IL, United States, 4Preventive Medicine, Northwestern University, Chicago, IL, United States, 5Biomedical Engineering, Northwestern University, Chicago, IL, United States

Stroke prevention is a major therapeutic goal in atrial fibrillation (AF) management. Flow quantification using MRI can provide information about left atrium hemodynamics implicated in stroke risk. This study evaluates the impact of cardiac arrhythmia on velocity and stasis, reflective of slow flow, measurements using both 4D-flow and real time phase contrast techniques in a cohort of healthy controls and AF patients in sinus rhythm and arrhythmia. Both real time phase contrast and 4D-flow showed a similar increase in left atrium stasis between controls and patients and between patients with low and high heart rate variability, but real time phase contrast was more sensitive to differences.

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