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Abstract #1204

Measuring Cardiac Strain in Duchenne Muscular Dystrophy with a Convolutional Neural Net Tag Tracking Method

Michael Loecher1,2, Luigi E Perotti3, Patrick Magrath4, and Daniel B Ennis1,2,5,6
1Radiology, Stanford, Palo Alto, CA, United States, 2Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 3Mechanical Engineering, University of Central Florida, Orlando, FL, United States, 4Radiology, University of California Los Angeles, Los Angeles, CA, United States, 5Cardiovascular Institute, Stanford, Palo Alto, CA, United States, 6Center for Artificial Intelligence in Medicine & Imaging, Stanford, Palo Alto, CA, United States

The objective of this work was to demonstrate the feasibility of using a convolutional neural net (CNN) based tag tracking algorithm for deriving strain measurements in grid tagged cardiac MR images. The method was tested in 23 subjects. When compared to commercial software the CNN-based method produces similar measurements for peak Ecc and shows lower strain in boys with DMD compared to healthy subjects [CNN = -0.15±0.03 vs -0.21±0.03] and [Conventional = -0.16±0.03 vs -0.21 ± 0.02] (p < .001). Peak Ecc was not significantly different within cohorts when compared between methods [DMD cohort: p=0.32, Healthy cohort: p=0.99]

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