Abstract #1217

Implementing multi-echo balanced SSFP with a sequential phase-encoding order at 7T

Huilou Liang^1,2, Ziyi Pan³, Chencan Qian^1,2, Kaibao Sun¹, Fanhua Guo^1,2, Dehe Weng⁴, Jing An⁴, Yan Zhuo^1,2,5, Hua Guo³, Danny J.J. Wang⁶, and Rong Xue^1,2,7

¹State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ⁴Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁵CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China, ⁶Laboratory of FMRI Technology (LOFT), Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ⁷Beijing Institute for Brain Disorders, Beijing, China

In the past decade, passband bSSFP has emerged as an alternative method to the widely-used GE-EPI in fMRI studies at high-fields. Multiline bSSFP with an interleaved phase-encoding order was further proposed to accelerate bSSFP fMRI. However, it intrinsically suffers from high spatial frequency ghosts which blur the image. In this study, we developed a multi-echo bSSFP sequence using a sequential phase-encoding order, combined with the GRAPPA technique for ghost elimination. In vivo experiments demonstrated that this sequence could shorten the imaging time and provide high-quality structural and functional MR images of the human brain at 7T with sub-millimeter resolution.

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