Multi-echo fMRI has been shown to provide better denoising and result in improved functional analysis compared to single-echo acquisition, but it reduces the temporal resolution and inhibits high-resolution imaging. Multi-band imaging and in-plane acceleration can compensate for the reduced resolution. The high performance gradient on a compact 3T scanner can further reduce the echo-spacing and accelerate the acquisition. Here we demonstrate that high spatial-resolution ME-MB fMRI is achievable with high temporal resolution on the compact 3T. The effectiveness of ME acquisition is evaluated with different artifact reduction strategies in whole brain resting-state fMRI and compared with the standard SE acquisition.
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