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Abstract #1220

Ultrahigh-resolution Laminar fMRI Mapping of Cat Visual Cortex at 9.4T: Comparison of 2D GE-EPI and 3D iv-GRASE Sequences

Wei Zhu1, Djaudat Idiyatullin1, Shinho Cho1, Yi Zhang1, Kâmil Uğurbil1, Xiao-Hong Zhu1, and Wei Chen1
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Blood oxygenation-level dependent (BOLD) fMRI studies at the level mesoscopic organizations, such as cortical columns and layers, is challenged by the low signal-to-noise ratio (SNR) and the specificity of different fMRI sequences even at ultrahigh magnetic fields. In this work, we show that when mapping layer-specific activities in the cat visual cortex, ultrahigh-resolution 3D GRASE sequence with inner volume selection achieved similar specificity as at 9.4 Tesla CBV-fMRI using 2D GE-EPI sequence, while attains a higher BOLD sensitivity. Our results indicate that 3D iv-GRASE BOLD is promising for laminar and columnar mapping of brain functions.

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