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Abstract #1221


Martin John MacKinnon1, Sheng Song1, Li-Ming Hsu1, Sung-Ho Lee1, G. Allan Johnson2, and Yen-Yu Ian Shih1
1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Duke University, Durham, NC, United States

In this study we demonstrate how a zero-echo-time (ZTE) technique can overcome several limitations of traditional fMRI experiments. We demonstrate that ZTE fMRI can detect functional activations with positive iron oxide contrast, termed iZTE-fMRI, at an approximate three-fold magnitude increase in tCNR when compared to GRE-techniques in-vivo - with the further potential demonstrated from phantom studies to increase tCNR more significantly under optimal contrast agent dose. We also show that iZTE fMRI experiments can produce functional images with markedly less susceptibility artifacts and acoustic noise than standard GRE techniques.

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