Functional MRI studies classically rely on the use of GE-EPI sequences. However, the GE-based signal is inherently sensitive to large veins, which impairs its use in high-resolution fMRI application. Other BOLD- and CBV-based approaches like SE-EPI and SS-SI-VASO, respectively, promise a higher specificity at the expense of sensitivity. In the present work, we tested if ocular dominance columns (ODCs) can be detected using GE-EPI, SE-EPI and SS-SI-VASO at 7 T. ODCs could be reliably mapped using all three acquisition methods. Furthermore, we could show for the first time ODCs in humans by exploiting the functional CBV response using SS-SI-VASO.
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