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Abstract #1231

Mapping directional functional connectivity across brain-wide networks with layer-specific CBV-fMRI

Laurentius Huber1, Emily Finn2, Sean Marrett2, Sriranga Kashyap1, Arman Khojandi2, Rainer Goebel1, Peter Bandettini2, and Benedikt Poser1
1MBIC, Uni Maastricht, Faculty of Psychology and Neuroscience, Maastricht, Netherlands, 2SFIM, NIMH, Bethesda, MD, United States

With recent advances in ultra-high-field MRI hardware and sequence mechanisms, it has become possible to measure CBV-weighted fMRI signal across cortical layers. While initial proof-of-principle layer-fMRI studies in primary brain areas with conventional fMRI task designs are promising, layer-fMRI has not yet realized its full potential to map layer-dependent functional connectivity across large-scale brain networks. In this study, we investigate the applicability of CBV-weighted layer-fMRI to assess functional connectivity during resting-state and naturalistic tasks. We can map common resting-state networks and characterize their internal layer-dependent signatures with respect to directionality and cortical hierarchy.

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