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Abstract #1232

In-vivo laminar CBF fMRI using high-resolution pseudo-continuous arterial spin labeling at 7T

Xingfeng Shao1, Kay Jann1,2, Kai Wang1, Fanhua Guo3, Peng Zhang3, and Danny JJ Wang1,2
1Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, University of Southern California, Los Angeles, CA, United States, 3State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

In-vivo laminar CBF fMRI was performed by high resolution (0.5×0.5×1.5 mm3) inner-volume GRASE with optimized pCASL labeling at 7T. Activation of finger-tapping task (5 blocks, TA=10 min) was reliably detected in all 4 subjects. Both rest/FT CBF peaks in the middle layers, which corresponds to highest capillary density in cortex layer IV. FT evoked CBF increase shows one peak in middle layer, and a second shoulder in deep layer. The capability to provide quantitative CBF measurements at both baseline and task activation with high specificity to neuronal activities is a unique strength of ASL fMRI compared to other fMRI techniques.

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