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Abstract #1239

Repetitive TMS increases whole brain metastability and dynamic integrity in Essential Tremor

SUJAS BHARDWAJ1, RAJANIKANT PANDA2, SHWETA PRASAD1, SUNIL KUMAR KHOKHAR3, SNEHA RAY3, ROSE DAWN BHARATH3, and PRAMOD KUMAR PAL1
1NEUROLOGY, NIMHANS, Bengaluru, India, 2Coma Science Group, Universitè de Liège, Liège, Belgium, 3NI & IR, NIMHANS, Bengaluru, India

We assessed the effect of repetitive transcranial magnetic stimulation (rTMS) on whole brain dynamics using fMRI. MRI was acquired before and after a single session of rTMS in 30 patients of Essential Tremor and 20 age matched healthy controls. Whole brain dynamic synchronization - “metastability”, and propagation of integration - “intrinsic ignition”, were studied in order to assess brain network topological fluctuations following rTMS. Single subject and group wise whole brain metastability, integration and ignition driven integration was found improve with a single session of rTMS.

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