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Abstract #1240

Diminished default mode network connectivity in older individuals is associated with aberrant brain metabolism

Xirui Hou1, Zixuan Lin1, Peiying Liu1, Corinne Pettigrew2, Anja Soldan2, Marilyn Albert2, and Hanzhang Lu1
1The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cerebral metabolic rate of oxygen (CMRO2), the rate at which O2 is consumed in the brain, is thought to be a direct index of energy hemostasis and brain health. Recent studies have suggested that CMRO2 is elevated but functional connectivity is declined with age. In this work, we demonstrated the diminished default network was associated with aberrant CMRO2 in older healthy subjects. Network analysis indicated that the increasing amount of CMRO2 was used to compensate for the inefficiency of degraded networks.

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