While radiation therapy plays an essential role in the management of brain tumor patients, exposure to radiation has been known to lead to declines in neurocognitive performance and vascular injury. As there remains a need for a reliable marker and predictor of patient outcome, this study explores the usefulness of functional connectivity measurements derived from 7T rsfMRI. We found that temporal properties, specifically low-frequency signals of some large-scale brain networks,are associated with more severe cognitive impairment and vascular injury, highlighting the potential benefit of using rsfMRI for treatment planningand prediction of patient outcome after RT.
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