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Abstract #1241

Functional connectivity is associated with radiotherapy-induced vascular injury and cognitive impairment in young brain tumor survivors

Melanie Morrison1, Angela Jakary1, Erin Felton2, Schuyler Stoller2, Sabine Mueller2, and Janine Lupo1
1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States

While radiation therapy plays an essential role in the management of brain tumor patients, exposure to radiation has been known to lead to declines in neurocognitive performance and vascular injury. As there remains a need for a reliable marker and predictor of patient outcome, this study explores the usefulness of functional connectivity measurements derived from 7T rsfMRI. We found that temporal properties, specifically low-frequency signals of some large-scale brain networks,are associated with more severe cognitive impairment and vascular injury, highlighting the potential benefit of using rsfMRI for treatment planningand prediction of patient outcome after RT.

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