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Abstract #1242

Effects of EGR3 transfection on behavior and resting-state fMRI in rats and evaluation of risperidone treatment in schizophrenia model

Xiaowei Han1,2, Guolin Ma1, and Lizhi Xie3
1Department of Radiology, China-Japan Friendship Hospital, Beijing, China, 2Graduate School of Peking Union Medical College, Beijing, China, 3GE Healthcare, MR Research China, Beijing, China

Schizophrenia is a neurodevelopmental psychiatric disorder with unclear etiology and no effective treatment. In this study, we established a new schizophrenia model in rats using early growth response (EGR3) gene transfection (lentivirus transfection) which was injected into the hippocampus and dentate gyrus of rats. The model was examined by evaluating the behavioral impact and cerebral alterations of schizophrenia model rats using behavioral phenotyping and resting-state functional magnetic resonance imaging (rs-fMRI). In addition, the efficacy of risperidone therapy was also evaluated in treated group rats. Briefly, we found several regional alterations in the cerebrum in amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo), which were consequently partially reversed by risperidone.

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