Xiaowei Han1,2, Guolin Ma1, and Lizhi Xie3
1Department of Radiology, China-Japan Friendship Hospital, Beijing, China, 2Graduate School of Peking Union Medical College, Beijing, China, 3GE Healthcare, MR Research China, Beijing, China
Schizophrenia is a neurodevelopmental psychiatric
disorder with unclear etiology and no
effective treatment. In this
study, we established a new schizophrenia model in rats using early growth response (EGR3) gene transfection (lentivirus transfection) which was injected into the hippocampus and dentate gyrus of
rats. The model was examined by evaluating the behavioral impact and cerebral
alterations of schizophrenia model rats using behavioral phenotyping and
resting-state functional magnetic resonance imaging (rs-fMRI). In addition, the
efficacy of risperidone therapy was also evaluated in treated group rats. Briefly, we found several regional alterations in the cerebrum in amplitude of low-frequency
fluctuations (ALFF) and regional homogeneity (ReHo), which were consequently partially
reversed by risperidone.
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