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Abstract #1245

Altered patterns of neural activity and functional connectivity revealed by dynamic rsfMRI in the Q175 mouse model of Huntington's disease

Tamara Vasilkovska1, Bram Callewaert1, Somaie Salajeghe1, Dorian Pustina2, Longbin Liu2, Mette Skinbjerg2, Celia Dominguez2, Ignacio Munoz-Sanjuan2, Annemie Van der Linden1, and Marleen Verhoye1
1Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium, 2CHDI Foundation, Princeton, NJ, United States

Static FC changes in neurodegeneration can indicate underlining neural mechanism pathology present in pre-manifest disease stage. In addition to the spatial FC component, quasi-periodic patterns (QPPs) implement spatiotemporal information of neural activity, allowing integrated assessment of possible initial changes in large-scale brain dynamics. We measured Low Frequency (LF) BOLD changes using rsfMRI in Q175 HD mouse model at 3 and 12 months of age. Results indicate decreased FC between specific regions in heterozygous compared to wild-type mice at 12 months. Both at 3 and 12 months, additional QPPs are present in the heterozygous group, deviating from the wild type group.

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