Abstract #1326

iSNAP sequence for simultaneous measurement of whole brain dynamic MRA, MRA, intracranial vessel wall and T1W structural brain MRI

Zhensen Chen¹, Zechen Zhou², Niranjan Balu¹, Haikun Qi³, Baocheng Chu¹, Thomas S Hatsukami⁴, and Chun Yuan¹

¹Vascular Imaging Lab and BioMolecular Imaging Center, Radiology, University of Washington, Seattle, WA, United States, ²Philips Research North America, Cambridge, MA, United States, ³Biomedical Engineering, King's College London, London, United Kingdom, ⁴Surgery, University of Washington, Seattle, WA, United States

In this study, a whole brain sequence named iSNAP, with 0.8 mm isotropic voxel size and 6 min 30 sec acquisition time, was developed to simultaneously obtain four different image contrasts (dynamic MRA [dMRA] for blood flow monitoring, MRA for luminal stenosis measurement, black blood image for vessel wall [VW] measurement and T1W for brain structural imaging). Preliminary testing results on a healthy volunteer and two patients with cerebrovascular diseases demonstrated the feasibility and potential of the sequence.

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