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Abstract #1328

Self-gated dynamic contrast enhanced magnetic resonance imaging of the aortic root in atherosclerotic mice: a natural progression study

Claudia Calcagno1, John David2, Abdallah Motaal2, Thijs Beldman2, Alexandra Corbin1, Arnav Kak1, Sarayu Ramachandran1, Alison Pruzan1, Raphael Soler1, Christopher Faries1, Zahi A. Fayad1, Willem Mulder1, and Gustav Strijkers2
1Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2University of Amsterdam, Amsterdam, Netherlands

Enhanced endothelial permeability is an important hallmark of atherosclerotic plaques at high-risk for causing severe cardiovascular events. Here we present a the application of a novel, self-gated DCE-MRI acquisition combined with compressed sensing reconstruction to quantify endothelial permeability in the mouse aortic root. In a longitudinal natural disease progression study in ApoE-/- mice, we find that plaque contrast agent washout computed from this acquisition changes significantly over time, with washout being slower in older mice.

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