Abstract #1328

Self-gated dynamic contrast enhanced magnetic resonance imaging of the aortic root in atherosclerotic mice: a natural progression study

Claudia Calcagno¹, John David², Abdallah Motaal², Thijs Beldman², Alexandra Corbin¹, Arnav Kak¹, Sarayu Ramachandran¹, Alison Pruzan¹, Raphael Soler¹, Christopher Faries¹, Zahi A. Fayad¹, Willem Mulder¹, and Gustav Strijkers²

¹Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²University of Amsterdam, Amsterdam, Netherlands

Enhanced endothelial permeability is an important hallmark of atherosclerotic plaques at high-risk for causing severe cardiovascular events. Here we present a the application of a novel, self-gated DCE-MRI acquisition combined with compressed sensing reconstruction to quantify endothelial permeability in the mouse aortic root. In a longitudinal natural disease progression study in ApoE-/- mice, we find that plaque contrast agent washout computed from this acquisition changes significantly over time, with washout being slower in older mice.

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