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Abstract #1338

Quantitative MRI and serum biomarkers detect acute and chronic vascular effects of e-cigarette use

Alessandra Caporale1, Shampa Chatterjee2, Michael C Langham1, Wensheng Guo3, Frank Leone4, Andrew Strasser5, and Felix W Wehrli1
1Radiology, Laboratory for Structural, Physiologic and Functional Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 2Physiology, Institute for Environmental Medicine, Perelman School of Medicine, Philadelphia, PA, United States, 3Biostatistics and Epidemiology, Perelman School of Medicine, Philadelphia, PA, United States, 4University of Pennsylvania Medical Center, Pulmonary, Allergy & Critical Care Division, Philadelphia, PA, United States, 5Psychiatry, Center for Interdisciplinary Research on Nicotine Addiction, Philadelphia, PA, United States

The vascular effects of e-cigarette use were investigated in young adults (19-35 years). Blood draws and 3T-MRI data were collected from seven e-cigarette users, seven smokers, thirty nonsmokers, the latter replicating the measurements after one nicotine-free e-cigarette vaping session. MRI-protocol measured peripheral vascular reactivity in response to cuff-induced ischemia, quantifying femoral artery luminal flow mediated dilation (FMDL), blood flow velocity, venous saturation (SvO2). FMDL decreased by 33% acutely after vaping, consistent with 20% NOx reduction and elevated inflammation (C-reactive protein increased by 95%). Reactive hyperemia was blunted as a chronic effect of both smoking and vaping, paired with anomalous biomarkers.

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