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Abstract #1340

Deciphering the contribution of extracellular glutamate and intracellular calcium signaling to the BOLD fMRI signal

Yuanyuan Jiang1, Xuming Chen2, Patricia Pais Roldán2, Bruce Rosen1, and Xin Yu1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Cambridge, MA, United States, 2Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

We established a multi-modal fMRI platform with two-channel fiber optic recording based on a genetically encoded fluorescent reporter, iGluSnFR, for extracellular glutamate (Glu) sensing and intracellular calcium indicator, GCaMP6f. Different from the intracellular neuronal and astrocytic calcium transients, the Glu signal, peak responses of spikes and baseline drift, show unique correlation features to the BOLD fMRI signal. Here, we applied the multi-modal fMRI platform to decipher the cellular and molecular interaction underlying the BOLD fMRI signal through the neuro-glio-vascular network in animal brains.

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Abstract