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Abstract #1344

Evaluation of an improved microelectrode array for MR-compatibility and MR-simultaneous recording performance in 7T research system

Xiao Yu1,2, Bo-Wei Chen3, Xiaojun Tan1,4, Boyi Qu1,4, Tingting He1,2, Ching-Fu Wang3, Yu-Hao Lan3, You-Yin Chen3, and Hsin-Yi Lai1,2
1Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou, China, 2Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China, 3Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, 4College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China

Simultaneous recording of electrophysiological signals with functional magnetic resonance imaging (fMRI) can provide a solution for investigation of neurovascular coupling. However, this technique is challenged by 2 aspects, image artifact from electrode and electrophysiological noise from magnetic field. We improved our pervious lab-designed microelectrode array and developed a de-noise method for use of its electrophysiological recording in 7T MRI. The results showed better structural image quality and stable acquisition of spike signals and local field potential. The proposed tool and method has the potential to facilitate simultaneous spike-recording during MR scanning in 7T MRI and further study the neurovascular coupling.

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