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Abstract #1345

Assessing the origin of human alpha oscillations using laminar layer 7T fMRI-EEG

Daniel C. Marsh1, Rodika Sokoliuk2, Kevin M. Aquino1,3, Daisie O. Pakenham1, Ross Wilson2, Rosa Sanchez Panchuelo1, Matthew J Brookes1, Simon Hanslmayr2, Stephen D. Mayhew2, Susan T Francis1, and Karen J Mullinger1,2
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, United Kingdom, 3Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia

EEG alpha (8-13Hz) oscillations occur throughout the cortex but the generating mechanisms are poorly understood. Opinion is divided between alpha being driven by bottom-up, top-down or both these processes. Here we use simultaneous 7T-fMRI-EEG during periods of eyes open/closed to assess the generator of alpha by determining the strongest BOLD-alpha negative layer correlations. We show the feasibility of using high spatial resolution 7T-fMRI with EEG to understand the origin of oscillations. Preliminary analysis shows BOLD-alpha correlations peak in middle layers of V1 (but not in V2/V3) providing suggestion that the alpha oscillations investigated are driven by bottom-up processing.

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