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Abstract #1346

Simultaneous fMRI/fMRE reveals BOLD and viscoelastic changes in the cerebellum during motor planning

Patricia S. Lan1, Kevin J. Glaser2, Richard L. Ehman2, and Gary H. Glover3
1Bioengineering, Stanford University, Stanford, CA, United States, 2Radiology, Mayo Clinic, Rochester, MN, United States, 3Radiology, Stanford University, Stanford, CA, United States

In this work, we demonstrate the first fMRE (functional MR elastography) activation in the cerebellum using a motor planning task. A block paradigm of 24s ON (auditory-cued button pressing) and 24s OFF (rest) was used and images were acquired with a single-shot spin-echo EPI MRE sequence. Our results show that tissue stiffness within the cerebellum increases with motor planning. Furthermore, the stiffness and BOLD activation colocalize in the cerebellum but do not match exactly, suggesting that the two modalities may reveal different aspects of the mechanisms for neural activation.

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