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Abstract #1347

Validation of MRI-based Oxygen Extraction Fraction (OEF) Measurement with 15O Positron Emission Tomography

Dengrong Jiang1, Shengwen Deng2, Crystal G. Franklin2, Michael O'Boyle2, Wei Zhang2, Betty L. Heyl2, Li Pan3, Paul A. Jerabek2, Peter T. Fox2, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 3Siemens Healthineers, Baltimore, MD, United States

Cerebral oxygen extraction fraction (OEF) is a potential biomarker in various diseases. The current gold standard to measure OEF is 15O-PET, but its clinical applications are impeded by inherent limitations. To facilitate broader clinical applications of OEF as a disease biomarker, in this work, we compared the whole-brain OEF measurement of a non-invasive MRI technique, T2-relaxation-under-spin-tagging (TRUST), with the gold standard PET measurement, and demonstrated a strong linear correlation and no systematic difference between the two methods.

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