Abstract #1347

Validation of MRI-based Oxygen Extraction Fraction (OEF) Measurement with 15O Positron Emission Tomography

Dengrong Jiang¹, Shengwen Deng², Crystal G. Franklin², Michael O'Boyle², Wei Zhang², Betty L. Heyl², Li Pan³, Paul A. Jerabek², Peter T. Fox², and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, ³Siemens Healthineers, Baltimore, MD, United States

Cerebral oxygen extraction fraction (OEF) is a potential biomarker in various diseases. The current gold standard to measure OEF is ¹⁵O-PET, but its clinical applications are impeded by inherent limitations. To facilitate broader clinical applications of OEF as a disease biomarker, in this work, we compared the whole-brain OEF measurement of a non-invasive MRI technique, T₂-relaxation-under-spin-tagging (TRUST), with the gold standard PET measurement, and demonstrated a strong linear correlation and no systematic difference between the two methods.

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