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Abstract #1358

Metabolic basis of activated and deactivated brain network nodes in fMRI paradigms

Yury Koush1, Robin A. de Graaf1, Ron Kupers2, Laurence Dricot3, Maurice Ptito4, Kevin Behar1, Douglas L. Rothman1, and Fahmeed Hyder1
1Yale University, New Haven, CT, United States, 2University of Copenhagen, Copenhagen, Denmark, 3University of Louvain, Louvain, Belgium, 4School of Optometry, Montreal, QC, Canada

Functional MRI using blood oxygenation level dependent (BOLD) contrast identifies brain regions for task-induced (de)activation paradigms. We investigated the metabolic basis of these paradigms in activated (visual cortex, VC) and deactivated (posterior cingulate cortex, PCC) network nodes using concurrent acquisitions of J-edited lactate/GABA(γ-aminobutyric acid)/Glx(pooled glutamate and glutamine) and diffusion-weighted BOLD signal. In VC, we detected increased BOLD/lactate/glutamate, and decreased GABA, whereas in PCC BOLD decreased, GABA increased but lactate/glutamate did not change. These results suggest that BOLD responses in (de)activated areas is regulated by relatively rapid GABAergic inhibition, whereas aerobic glycolysis and glutamatergic activity dominate in activated nodes.

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