Abstract #1359

Employing simultaneous functional PET/MRI to map neuronal and vascular dynamics accompanying brain arousal fluctuations

Jingyuan E Chen^1,2, Nina E Fultz¹, Jonathan R Polimeni^1,2, Ciprian Catana^1,2, Bruce R Rosen^1,2, Laura D Lewis³, and Christin Y Sander^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Biomedical Engineering, Boston University, Boston, MA, United States

In this study, we investigated the feasibility of integrating simultaneous fMRI and functional PET to uncover metabolic and hemodynamic changes linked with arousal. Our findings suggested that this multi-modal toolset can reliably detect brain-wide hemodynamic and metabolic changes spanning “alert”, “drowsy” and “sleep” conditions, therefore holding great promise in disentangling arousal-induced neuronal and vascular dynamics in future investigations.

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