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Abstract #1361

The Stomach and the Brain are Synchronized Intrinsically in Rats

Jiayue Cao1, Xiaokai Wang1, Kun-Han Lu2, Zhenjun Tan3, Robert Phillips3, Deborah Jaffey3, Terry Powley3, and Zhongming Liu1,2
1Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, 3Psychological Science, Purdue University, West Lafayette, IN, United States

The origins of fMRI in the resting state has been widely explored but yielded incomplete knowledge. Here, we hypothesize that gastric activity contributes to intrinsic brain activity observed with fMRI.We explored the gut-brain synchrony in rats by recording the electrogastrogram together with fMRI. We found that brainactivity is intrinsically synchronized with gastric activity at a specific resting state network in which the BOLD activity is time-locked to gastric activity with varying time delays.

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