Abstract #1367

White matter resting-state BOLD signals depend on the orientation of the local diffusion tensor axis relative to the B0-field

Olivia Viessmann¹, Qiyuan Tian¹, Michaël Bernier¹, David H Salat^1,2, and Jonathan Rizzo Polimeni^1,3

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²VA Boston Healthcare System, Boston, MA, United States, ³Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

We aimed to test whether the amplitudes of resting-state BOLD signals within the white matter depend on the orientation of the local diffusion tensor relative to the B₀-field. This was assessed using resting-state BOLD and diffusion data provided by the HCP. Baseline BOLD signals were about 11% higher in voxels where primary DTI directions were parallel to B₀ compared to perpendicular. Because myelinated fibres will change local tissue T₂*, which will also impact the BOLD signal, we tested whether the observed BOLD orientation effect was driven by static effects on the baseline or dynamic effects from changes in blood oxygenation.

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