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Abstract #1368

Contrasting brain MRI features in Ab-mediated demyelinating diseases and MS: investigating the pathogenesis of brain damage

Silvia Messina1, Romina Mariano1, Adriana Roca-Fernandez1, Ana Cavey1, Rosie Everett2, Sandra Reeve2, Maria Isabel Leite1, Mark Jenkinson1,3, and Jacqueline Palace1
1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Oxford University Hospital NHS Foundation Trust, Oxford, United Kingdom, 3University of Adelaide, Adelaide, Australia

The previous non-conventional MRI studies included both AQP4 positive and negative patients, thus yielding differing results, partly explained by cohort heterogeneity (i.e. antibodies status). No studies are available in MOG-Ab disease. We compared, using non-conventional imaging, brain MRI findings in 73 subjects with AQP4-ab, MOG-Ab disease, Multiple Sclerosis and in healthy controls. We found that MOG-Ab disease have a lower lesions load when compared to MS and AQP4-Ab disease and we demonstrated, for the first time, that significant changes occur in the deep grey matter while no significant changes were detected in the non-lesional white matter in MOG-Ab disease.

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