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Abstract #1369

Multi-modal Cervical Cord MRI in MOGAD, AQP4-Ab NMOSD & MS

Romina Mariano1, Silvia Messina1, Adriana Roca-Fernandez1, Ana Cavey1, Rosie Everett2, Maria Isabel Leite1, Yazhuo Kong1,3, and Jacqueline Palace1
1Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 2Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, 3The Key Laboratory of Behaviour Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China

Spinal cord involvement is an important feature of antibody-mediated demyelination, as in AQP4-Ab-positive NMOSD and MOGAD, as well as in MS. In this study of 80 participants (20 MOGAD, 20 AQP4-Ab, 20 MS, 20 health volunteers) we use multimodal cervical cord MRI to show that MOGAD may predominantly affect the grey matter; AQP4-Ab disease shows the most severely affected cord, localised to lesional areas; and that MRI metrics in the cervical cord do not differentiate these three conditions but have clinical relevance in their association with disability and pain scores, independent of disease type.

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