Spinal cord involvement is an important feature of antibody-mediated demyelination, as in AQP4-Ab-positive NMOSD and MOGAD, as well as in MS. In this study of 80 participants (20 MOGAD, 20 AQP4-Ab, 20 MS, 20 health volunteers) we use multimodal cervical cord MRI to show that MOGAD may predominantly affect the grey matter; AQP4-Ab disease shows the most severely affected cord, localised to lesional areas; and that MRI metrics in the cervical cord do not differentiate these three conditions but have clinical relevance in their association with disability and pain scores, independent of disease type.
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