Abstract #1377

Thalamic volume relates to future memory performance in Multiple Sclerosis

Katherine A Koenig¹, Jian Lin¹, Daniel Ontaneda², Kedar Mahajan², Jenny Feng², Stephen M. Rao³, Sanghoon Kim¹, Stephen J Jones¹, and Mark J Lowe¹

¹Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, ²Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, ³Schey Center for Cognitive Neuroimaging, The Cleveland Clinic, Cleveland, OH, United States

Cognitive dysfunction is a common symptom of Multiple Sclerosis (MS), and patients would benefit from a measure that estimates their risk of future decline. Previous work suggests that thalamic volume may have value as a predictive measure. Using 7 tesla MRI, we measured thalamic volume in 79 participants with MS. We found a strong cross-sectional relationship between volume and verbal episodic memory. The longitudinal relationship was significant, but was strongly modulated by disease duration. The current report highlights the need for careful modeling of potential confounding variables.

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