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Abstract #1376

Declining frontoparietal connectivity is linked to decreased episodic memory performance in multiple sclerosis

Katherine A Koenig1, Jian Lin1, Daniel Ontaneda2, Kedar Mahajan2, Jenny Feng2, Stephen M. Rao3, Sanghoon Kim1, Stephen J Jones1, and Mark J Lowe1
1Imaging Sciences, The Cleveland Clinic, Cleveland, OH, United States, 2Neurological Institute, The Cleveland Clinic, Cleveland, OH, United States, 3Schey Center for Cognitive Neuroimaging, The Cleveland Clinic, Cleveland, OH, United States

Cognitive dysfunction, often including memory loss, impacts about half of those with Multiple Sclerosis (MS). Our work aims to develop a predictor of future memory decline in MS. Using high resolution MRI, we measured resting state functional connectivity of the frontoparietal network in 77 participants with MS. We found that connectivity was related to episodic memory at baseline, and that the one-year change in connectivity was related to the change in memory performance. This finding suggests that functional connectivity can be developed as a predictor of memory decline in MS.

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