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Abstract #1379

Characterizing dynamic functional connectivity in the main clinical phenotypes of multiple sclerosis

Paola Valsasina1, Milagros Hidalgo de la Cruz1, Francesca Sangalli2, Federica Esposito2, Massimo Filippi1,2,3, and Maria A. Rocca1,2
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy

In this study, we used dynamic functional connectivity (dFC) to characterize time-varying connectivity abnormalities in patients with multiple sclerosis (MS) with the main disease phenotypes. Compared to controls, MS patients presented overall dFC reduction in all networks, along with increased dFC in sensorimotor, default-mode and frontal/attention networks. While progressive MS showed additional dFC decrease vs relapsing-remitting (RR) MS, in benign MS the overall reduction of dFC was accompanied by significantly increased dFC in the sensorimotor, default-mode and frontal/attention networks. Reduced dFC correlated with more severe clinical disability and worse cognitive performance.

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