Abstract #1379

Characterizing dynamic functional connectivity in the main clinical phenotypes of multiple sclerosis

Paola Valsasina¹, Milagros Hidalgo de la Cruz¹, Francesca Sangalli², Federica Esposito², Massimo Filippi^1,2,3, and Maria A. Rocca^1,2

¹Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, ²Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ³Vita-Salute San Raffaele University, Milan, Italy

In this study, we used dynamic functional connectivity (dFC) to characterize time-varying connectivity abnormalities in patients with multiple sclerosis (MS) with the main disease phenotypes. Compared to controls, MS patients presented overall dFC reduction in all networks, along with increased dFC in sensorimotor, default-mode and frontal/attention networks. While progressive MS showed additional dFC decrease vs relapsing-remitting (RR) MS, in benign MS the overall reduction of dFC was accompanied by significantly increased dFC in the sensorimotor, default-mode and frontal/attention networks. Reduced dFC correlated with more severe clinical disability and worse cognitive performance.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.