We utilized an approach combining DTI, RS-fMRI and graph-theory to characterize the relation between cognitive profiles and global and local network features in RRMS patients with mild to moderate disability. Closer association of structural network metrics with cognitive abilities were seen compared to standard-MRI outcomes and an interesting pattern of associations with a slight predominance of nodes located in the default mode network (DMN). While structural connectivity always showed a positive correlation with performance, the number of functional connections of nodes was mostly negatively correlated. DMN had inverse and direct relationships with memory, possible indicating adaptive and maladaptive mechanisms.
This abstract and the presentation materials are available to members only; a login is required.